Prof. Dr. Ramez Reda Moustafa is currently Professor of Neurology at Ain Shams University,
Cairo, Egypt.
He held the position of Director of the Neurology Unit at Ain Shams University Specialized
Hospital until 2012, and served as a Consultant Neurologist at several major hospitals across
Cairo.
In 1998, Prof. Moustafa graduated with a Bachelor of Medicine and Surgery from Ain Shams
University, following which he received training in neurology and psychiatry, first in Cairo,
and then in Cambridge, UK, where he was awarded his PhD. He is also a member of the
Royal College of Physicians.
Prof. Moustafa specializes in stroke and cerebrovascular diseases, migraine, and sleep
medicine. He has several publications in top international medical journals, and has
published several books and book chapters. In 2012, he received the Egyptian National
Award for scientific research.
Education
- PhD in Neurology
- University of Cambridge, Cambridge, United Kingdom (2004- 2009)
- Clinical research on the applications of advanced functional & structural neuroimaging (PET & MRI) in patients with acute ischemic stroke and carotid artery disease
- Supervised by Professor Jean-Claude Baron and Dr. Elizabeth A Warburton
- MD in Neurology (2007)
- Ain Shams University, Cairo, Egypt
- Membership of the Royal College of Physicians (UK)
- Royal College of Physicians of London, United Kingdom (2005)
- MSc in Neurology & Psychiatry
- Faculty of Medicine, Ain Shams University, Cairo, Egypt (2002)
- Taught courses in neuroanatomy, neurophysiology, biochemistry, neurohistology, neuropathology, psychopathology, psychology, clinical neurology, clinical psychiatry and internal medicine
- Essay on “Intra-operative neurophysiologic monitoring during spine surgery”
- Grade: Excellent
- Bachelor of Medicine and Surgery (MB BCh)
- Faculty of Medicine, Ain Shams University, Cairo, Egypt (1998)
- Grade: Excellent with first degree honors
Current Position: Professor of Neurology, Faculty of Medicine, Ain Shams University
Unit(s)
Skills & Interests
Ramez Reda specializes in stroke and cerebrovascular diseases, migraine, and sleep
medicine.
1- Cerebrovascular diseases/Stroke
§ Training as resident and later as assistant lecturer in the Stroke Unit at Ain Shams University Specialized Hospital, Cairo, Egypt
§ Deputy Director of the Stroke Unit at Ain Shams University Specialized Hospital, Cairo, Egypt (2009)
§ Extensive experience in stroke patients management including imaging, critical care, thrombolysis, acute care, primary and secondary prevention
§ Experience with all multi-modality imaging techniques used in stroke (CT, MR, PET, SPECT, Angiography, Ultrasonography, Vascular Doppler)
§ Trained at Lewin Stroke and Rehabilitation Unit, Addenbrooke’s Hospital, Cambridge, UK (2004-2007)
§ Broad experience in stroke research during MD and PhD studies and afterwards as academic lecturer
§ First prize in Cambridge EUSI summer school 2006
2- Imaging and Positron Emission Tomography (PET)
§ Trained at the Wolfson Brain Imaging Centre, Cambridge, UK (2004-2007)
§ Experience in design and conduct of studies and PET scanning
§ Attended several PET and MR theory courses including safety, management and biophysics
§ Broad experience in analysis and interpretation of neurology PET scans including experience on:
§ 18F-FDG in brain metabolism, Alzheimer’s Disease and fronto-temporal dementia
§ 18F-FDG in Carotid, aorta and arterial tree atherosclerosis
§ Triple 15O studies on cerebral blood flow, blood volume and oxygen metabolism (15O2, H215O, C15O) in cases of acute and chronic ischaemia
§ 11C-PK11195 in brain inflammation and in carotid artery macrophage recruitment
§ 18F-DOPA in Parkinson’s Disease
§ 18F-FMISO in acute stroke
§ Experience in organization and management of PET and imaging centre
§ Experience in working with a vast team of physicists, mathematicians, chemists and radiographers involved in PET
3- Sleep Medicine
§ Trained at Ain Shams University sleep lab and later in UK
§ Founder and medical director of a pioneering private sleep centre in Cairo, Egypt “Sleep Care Clinic (www.sleepcareclinic.com)”
§ Extensive experience in clinical management of sleep disorders
§ Set protocols for polysomnography, PAP titration, mobile testing and actigraphy
§ Ongoing CME training in sleep medicine and active participation in international sleep societies
§ Experience in organizing multi-disciplinary team sleep meetings involving neurologists, psychiatrists, chest physicians, ENT surgeons and paediatricians
§ Active research program on sleep apnoea and its relationship to epilepsy and migraine
4- Headache and Migraine
§ Founding member and secretary of the Headache Chapter of the Egyptian Society of Neurology (International headache society affiliate)
§ Head of headache research group, department of neurology, Ain Shams University
§ Organized several scientific events on migraine including the 3rd MENA Headache conference, Cairo 2018
§ Editorial board member of CGRP forum (www.cgrpforum.org)
Thesis
PhD in Neurology ,University of Cambridge, Cambridge, United Kingdom 2004- 2009
– Clinical research on the applications of advanced functional & structural neuroimaging (PET & MRI) in patients with acute ischemic stroke and carotid artery diseasesupervised by Professor Jean-Claude Baron and Dr. Elizabeth A Warburton.
MD in Neurology 2007 ,Ain Shams University, Cairo, Egypt
– Intracranial atherosclerosis in patients with recurrent stroke supervised by Prof. Anwar el-Etribi, Prof. Ossama Abdul Ghani and Prof. Hany Aref
Training
Academic & Professional Experience
Professor of Neurology
Ain Shams University, Cairo, Egypt 2018 – present
§ Weekly teaching of neurology to undergraduate and postgraduate medical students through lectures and clinical tutorials
§ Weekly clinical round to consult on medical Management of neurology and stroke cases in the university hospital
§ Supervising and conducting research studies on neurology with a special interest in stroke, migraine and neuroimaging
§ Participation in setting and administering post-graduate neurology examinations (master’s and MD level)
Assistant Professor of Neurology
Ain Shams University, Cairo, Egypt 2012 – 2018
§ Weekly teaching of neurology to undergraduate and postgraduate medical students through lectures and clinical tutorials
§ Weekly clinical round to consult on medical Management of neurology and stroke cases in the university hospital
§ Supervising and conducting research studies on neurology with a special interest in stroke and neuroimaging
§ Participation in setting and administering post-graduate neurology examinations (master’s and MD level)
Director of Neurology Unit
Ain Shams University Specialized Hospital, Cairo, Egypt 2011 – 2012
§ Supervise and oversee patient care in a 26-bed unit with a specialized epilepsy monitoring unit and a sleep lab
Lecturer of Neurology
Ain Shams University, Cairo, Egypt 2007 – 2012
§ Weekly teaching of neurology to undergraduate and postgraduate medical students through lectures and clinical tutorials
§ Weekly clinical round to consult on medical Management of neurology and stroke cases in the university hospital
§ Supervising and conducting research studies on neurology with a special interest in stroke and neuroimaging
Consultant Neurologist 2007 – present
Ain Shams University Specialized Hospital, Cairo, Egypt
Nozha International Hospital, Cairo, Egypt
Cleopatra Hospital, Cairo, Egypt
Clinical Fellow/Registrar 2005 – 2009
Addenbrooke’s Hospital, Cambridge, UK
§ Active clinical role in activities in the department of clinical neurosciences and Lewin Stroke & Rehabilitation Unit
§ Participation and case demonstrations at weekly ward rounds and clinical conference
§ Stroke on-call registrar duty once per week
§ Weekly neurovascular clinic
§ Recruitment of research volunteers and patient recruitment into clinical trails (e.g. IST-3, ECASS III, PERFORM)
Assistant Lecturer of Neurology
Ain Shams University, Cairo, Egypt 2003 – 2007
§ Bedside clinical teaching for neurology residents
§ Administering periodic undergraduate neurology exams in the Multiple Choice Questions format and the clinical viva exam format
§ Clinical teaching of postgraduate neurology students on diagnosis and management of neurological conditions and theoretical neuroscience
§ Participating in ongoing departmental research projects with a focus on stroke neurology. Responsibilities include patient recruitment, clinical assessment, administration of scales, data gathering and analysis
§ Supervising medical management of general neurology inpatients within the department of neurology
§ Assessment and management of outpatients in cerebro-vascular and epilepsy clinics in rotation with other specialists
§ Evaluation and follow up of neurology residents’ performance
§ Administering and interpretation of clinical neurophysiology tests including EEG, evoked potentials and EMG with a special interest in Intra-operative neurophysiology
Neurology Specialist 2003 – 2004
Nozha International Hospital, Cairo, Egypt
Description:
§ A multi-specialty 200-bed private hospital with an active neurology service (average intake 10 patients per week)
Duties:
§ Assisting in management and follow-up of neurology inpatients on a part time basis
§ Overnight on call neurologist once per week
Accident & Emergency Neurologist 2003 – 2004
Ain Shams University Specialized Hospital, Cairo, Egypt
§ Neurologist on duty once per week
§ Main responsibilities include assessment and management of neurologic emergencies (particularly acute stroke) and providing neurologic opinion on other medical and surgical patients.
Resident of Neurology and Psychiatry
Ain Shams University, Cairo, Egypt 2000 – 2003
1. Ain Shams Specialized Hospital
§ Stroke unit
Unit description:
- A 35-bed facility with 8 intermediate care beds providing top class management of acute stroke. Services include intravenous thrombolysis for hyperacute stroke and advanced MRI
Duties
- Clinical assessment and management planning for new admissions
- Daily progress follow up and management of concurrent and emergent conditions
- Daily round with unit director to supervise performance
- Presentation of cases of interest bimonthly
Duration of training:
- Four months
§ Neurology unit
Unit description:
- A 20-bed facility serving as a referral centre for Cairo dedicated to diagnosis and treatment of neurologic diseases with access to a complete neurophysiology lab and neuropathology lab and neuroimaging facilities.
Duties
- Initial assessment and diagnosis with a focus on clinical skills
- Setting plans for diagnosis, investigation and treatment of inpatients.
- Daily round with unit director to supervise performance
Duration of training:
- Four months
§ Accident & Emergency Unit
Unit description:
- A general intake emergency unit with high-dependency care facilities employing a multi-disciplinary team of specialists dedicated to A&E management
Duties
- Initial assessment and immediate intervention in emergent medical conditions especially neurological events including hyperacute stroke
- Intense collaboration with the team members on cases with multiple medical and/or surgical conditions
- Member of the resuscitation and life support team
Duration of training:
- Six months
2. Department of Neurology & Psychiatry
§ Neuro-Critical Care Unit
Unit description:
- A 5-bed facility within the department for management of severely ill patients requiring continuous vital and neurologic monitoring, mechanical ventilation and intensive follow-up.
Duties
- Management of neurologic emergencies
- Assessment, diagnosis and management of patients with severe medical conditions
- Provision of training sessions for junior staff and nursing on basic resuscitation and life support
Duration of training:
- Four months
§ Neurology Unit
Unit description:
- Reputed referral and educational centre with a wide range of investigative and therapeutic facilities
Duties
- Managed outpatient clinics on a regular twice weekly basis
- Responsible for admission, management planning and provision for inpatients in the unit
- Presenting cases in weekly conference
- Consultation liaison neurologist to the medical and surgical departments
Duration of training:
- Ten months
3. Institute of Psychiatry
§ Adult Psychiatry Unit
Unit description:
- Seventy-bed hospital serving psychiatric patients in the Cairo area
Duties
- Diagnosis and management of most psychiatric conditions under guidance
- Provisioning of electro-convulsive and pharmacologic therapy for patients
- Supervising rehabilitation programs
- Follow up of outpatients three times a week in clinic
- Presenting cases in weekly conference
- Management of various psychiatric emergencies in ER
Duration of training:
- Twelve months
§ Addiction Unit
Unit description:
- Twenty beds within the institute dedicated to the management of polysubstance abuse patients
Duties
- Working under supervision on tailoring therapeutic plans for patients
- Provisioning of individual and group psychotherapy sessions
- Provisioning of pharmacologic and medical treatment for these patients
- Supervising rehabilitation programs
- Follow up of outpatients in weekly clinic
Duration of training:
- Three months
House Officer 1999-2000
Ain Shams University Hospitals, Cairo, Egypt & Al Matareya Teaching Hospital, Cairo, Egypt
§ Received general medical training in the following clinical departments – Haematology, General Surgery, Gynaecology, Neuropsychiatry, Paediatrics, & Emergency Medicine
§ Received emergency medicine training in general intake A&E department twice per week
§ Responsibilities included assisting in patient management, organizational tasks and training on manual clinical skills
Publications
Selected Published Papers
- Alawneh JA, Moustafa RR, Baron JC. Hemodynamic factors and perfusion abnormalities in early neurological deterioration. Stroke. 2009;40:e443-450
- Alawneh JA, Moustafa RR, Marrapu ST, Jensen-Kondering U, Morris RS, Jones PS, et al. Diffusion and perfusion correlates of the f-miso pet lesion in acute stroke: Pilot study. Eur J Nucl Med Mol Imaging. 2013
- Donswijk ML, Jones PS, Guadagno JV, Carpenter TA, Moustafa RR, Fryer TD, et al. T2*-weighted mri versus oxygen extraction fraction pet in acute stroke. Cerebrovasc Dis. 2009;28:306-313
- Emara TH, Moustafa RR, Elnahas NM, Elganzoury AM, Abdo TA, Mohamed SA, et al. Repetitive transcranial magnetic stimulation at 1hz and 5hz produces sustained improvement in motor function and disability after ischaemic stroke. Eur J Neurol. 2010;17:1203-1209
- JM UK-I, Tang T, Moustafa RR, Baron JC, Warburton EA, Gillard JH. Imaging the cellular biology of the carotid plaque. Int J Stroke. 2007;2:85-96
- Khaleel SH, Bayoumy IM, El-Nabil LM, Moustafa RR. Differential hemodynamic response to repetitive transcranial magnetic stimulation in acute stroke patients with cortical versus subcortical infarcts. Eur Neurol. 2010;63:337-342
- Moustafa RR, Allen CM, Baron JC. Call-fleming syndrome associated with subarachnoid haemorrhage: Three new cases. J Neurol Neurosurg Psychiatry. 2008;79:602-605
- Moustafa RR, Allen CM, Baron JC. Call-fleming syndrome associated with subarachnoid haemorrhage: Three new cases. BMJ Case Rep. 2009;2009
- Moustafa RR, Antoun NM, Coulden RA, Warburton EA, Baron JC. Stroke attributable to a calcific embolus from the brachiocephalic trunk. Stroke. 2006;37:e6-8
- Moustafa RR, Baron JC. Imaging the penumbra in acute stroke. Curr Atheroscler Rep. 2006;8:281-289
- Moustafa RR, Baron JC. Clinical review: Imaging in ischaemic stroke–implications for acute management. Crit Care. 2007;11:227
- Moustafa RR, Baron JC. Pathophysiology of ischaemic stroke: Insights from imaging, and implications for therapy and drug discovery. Br J Pharmacol. 2008;153 Suppl 1:S44-54
- Moustafa RR, Izquierdo D, Weissberg PL, Baron JC, Warburton EA. Neurological picture. Identifying aortic plaque inflammation as a potential cause of stroke. J Neurol Neurosurg Psychiatry. 2008;79:236
- Moustafa RR, Izquierdo D, Weissberg PL, Baron JC, Warburton EA. Identifying aortic plaque inflammation as a potential cause of stroke. BMJ Case Rep. 2009;2009:bcr2007123232
- Moustafa RR, Izquierdo-Garcia D, Fryer TD, Graves MJ, Rudd JH, Gillard JH, et al. Carotid plaque inflammation is associated with cerebral microembolism in patients with recent transient ischemic attack or stroke: A pilot study. Circ Cardiovasc Imaging. 2010;3:536-541
- Moustafa RR, Izquierdo-Garcia D, Jones PS, Graves MJ, Fryer TD, Gillard JH, et al. Watershed infarcts in transient ischemic attack/minor stroke with > or = 50% carotid stenosis: Hemodynamic or embolic? Stroke. 2010;41:1410-1416
- Moustafa RR, Momjian-Mayor I, Jones PS, Morbelli S, Day DJ, Aigbirhio FI, et al. Microembolism versus hemodynamic impairment in rosary-like deep watershed infarcts: A combined positron emission tomography and transcranial doppler study. Stroke. 2011;42:3138-3143
- Moustafa RR, Moneim AA, Salem HH, Shalash AS, Azmy HA. Intracranial steno-occlusive arterial disease and its associations in egyptian ischemic stroke patients. Stroke. 2013;44:538-541
- Takasawa M, Moustafa RR, Baron JC. Applications of nitroimidazole in vivo hypoxia imaging in ischemic stroke. Stroke. 2008;39:1629-1637
- Tang TY, Moustafa RR, Howarth SP, Walsh SR, Boyle JR, Li ZY, et al. Combined pet-fdg and uspio-enhanced mr imaging in patients with symptomatic moderate carotid artery stenosis. Eur J Vasc Endovasc Surg. 2008;36:53-55
- Abd-Allah F, Khedr E, Oraby MI, Bedair AS, Georgy SS, Moustafa RR. Stroke burden in Egypt: data from five epidemiological studies. Int J Neurosci. 2018 Aug;128(8):765-771.
- Zakaria MF, Aref H, Abd ElNasser A, Fahmy N, Tork MA, Fouad MM, ElBokl A, Roushdy T, ElFaramawy S, El-Shiekh MA, Moustafa RR. Egyptian experience in increasing utilization of reperfusion therapies in acute ischemic stroke. Int J Stroke. 2018 Jul;13(5):525-529.
- Khater AH, Sobhy MH, Said HG, Kandil A, Reda W, Seifeldin AF, Moustafa R, Elassal MA, Kamel EM. Latarjet Procedure for Anterior Shoulder Instability Due to Tramadol-Induced Seizures: A Multicenter Study. Am J Sports Med. 2016 Apr;44(4):957-62.
- Shalash AS, Elrassas HH, Monzem MM, Salem HH, Abdel Moneim A, Moustafa RR. Restless legs syndrome in Egyptian medical students using a validated Arabic version of the Restless Legs Syndrome Rating Scale. Sleep Med. 2015 Dec;16(12):1528-31
- Abd-Allah F, Kissani N, William A, Oraby MI, Moustafa RR, Shaker E, El-Tamawy MS, Shakir R. Neuroscience research in Africa: Current status. eNeurologicalSci. 2015 Nov 10;3:7-10.
- Hussein HM, Abdel Moneim A, Emara T, Abd-Elhamid YA, Salem HH, Abd-Allah F, Farrag MA, Tork MA, Shalash AS, Ezz El Dein KH, Osman G, Georgy SS, Ghali PG, Lyden PD, Moustafa RR. Arabic cross cultural adaptation and validation of the National Institutes of Health Stroke Scale. J Neurol Sci. 2015 Oct 15;357(1-2):152-6.
- Abd-Allah F, Moustafa RR. Burden of stroke in Egypt: current status and opportunities. Int J Stroke. 2014 Dec;9(8):1105-8.
- Dwedar AZ, Ashour S, Haroun M, El Nasser AA, Moustafa RR, Ibrahim MH, Elsadek A. Sonothrombolysis in acute middle cerebral artery stroke. Neurol India. 2014 Jan-Feb;62(1):62-5.
Book Chapters
Moustafa RR, Baron JC. Perfusion thresholds in cerebral ischemia in The Ischemic Penumbra, Donnan, Baron, Davis and Sharp Eds. Taylor and Francis, London, 2007
Published Abstracts
- Moustafa RR, Izquierdo-Garcia D, Fryer TD, Graves MJ, Gillard JH, Weissberg PL, Baron JC, Warburton EA. Symptomatic carotid plaque inflammation is more intense following TIA than completed stroke: evidence from FDG PET. Cerebrovasc Dis 2008;25(suppl 2):4
- Awadh MM and Moustafa RR. Near total improvement of isolated cortical deficit in acute infarctions with loading clopidogrel after 3 days from stroke onset: case reports. Cerebrovasc Dis 2008;25(suppl 2):115
- Awadh MM, Ragab SA, Sherif HM, Afifi HM, Aref HM, Moustafa RR, Abdulghani MO. Single loading doses of clopidogrel are well tolerated in ischemic stroke up to 24 hours from onset. Cerebrovasc Dis 2008;25(suppl 2):180
- Moustafa RR, Allen CMC, Baron JC. Subarachnoid haemorrhage in the reversible cerebral vasoconstriction (Call-Fleming) syndrome: Main features. Cerebrovasc Dis 2008;25(suppl 2):189
- Etribi MA, Ashour SM, Abdo TA, Elnahas NM, Elganzoury AM, Moustafa RR, Emara TH. Marked motor improvement in post-stroke patients with severe hand weakness following repetitive transcranial magnetic stimulation (RTMS): a report of Int J stroke 2008;(3):329
- Etribi MA, Ashour SM, Abdo TA, Elnahas NM, Elganzoury AM, Moustafa RR, Emara TH. Cortical involvement may predict response to repetitive transcranial magnetic stimulation (RTMS) in stroke patients with hemiparesis. Int J stroke 2008;(3):333
- Etribi MA, Ashour SM, Abdo TA, Elnahas NM, Elganzoury AM, Moustafa RR, Emara TH. Safety of 5 Hz repetitive transcranial magnetic stimulation (rTMS) using a continuous .5-minute pulse train protocol in chronic stroke patients. Int J stroke 2008;(3):341
- Etribi MA, Ashour SM, Abdo TA, Elnahas NM, Elganzoury AM, Moustafa RR, Emara TH. Ipsi-lesional 5 Hz versus contra-lesional Hz repetitive transcranial magnetic stimulation (rTMS) in rehabilitation of hand function after stroke. Int J stroke 2008;(3):350
- Etribi MA, Ashour SM, Abdo TA, Elnahas NM, Elganzoury AM, Moustafa RR, Emara TH. Sustained motor function improvement months following a week course of repetitive transcranial magnetic stimulation (RTMS) in stroke patients. Int J stroke 2008;(3):408
- Donswijk ML, Jones PS, Guadagno JV, Williams G, Harding S, Carpenter TA, Moustafa RR, Fryer TD, Aigbirhio FI, Warburton EA, Baron J-C. Does T2* MR reliably represent the oxygen extraction fraction (OEF) in acute ischemic stroke? Comparison to quantitative positron emission tomography. Int J Stroke 2008;(3):447
Peer review
- Referee for several international peer-reviewed journals and publishers: 2006-present
- Circulation
- Brain
- Stroke
- Journal of Neuroscience Methods
- Journal of Neuroimaging
- Brain Research Bulletin
- Journal of Neurology, Neurosurgery and Psychiatry
- Brain Stimulation
- Wiley-Blackwell books
Research projects
- Successful Egyptian National Science and Technology Development Fund (STDF) grant awarded to establish a state-of-the-art Neuromodulation Center at Ain Shams University (2010, Capacity building Grant: 250,000 EUR)
- Designed and supervised several clinical research and imaging studies in neurology, stroke and sleep medicine at Ain Shams University, Egypt and the University of Cambridge, UK
- Tasks included formulating the research protocol, obtaining ethical approval, patient recruitment and consent, running the study procedures, team-building and research team management and data acquisition and analysis
Conferences & Presentations
- Platform Presentation on “Clopidogrel loading in acute ischemic stroke”, European stroke conference, Milan, Italy, May 2019
- Platform presentation on “Actigraphy in Neurologic Practice”, Cairo Neurology Conference, Mar 2010, Sharm El Sheikh, Egypt
- Platrform presentation on “Gender differences in sleep disorders”, Ain Shams University conference, May 2010, Cairo, Egypt
- Platform presentation on “Carotid FDG PET in TIA vs. Stroke”, 17th European Stroke Conference, Nice, France, May 2008
- Platform presentation on “Thunderclap headache”, Cairo Neurology Conference, Feb 2008, Cairo, Egypt
- Various presentations at Darwin college, Cambridge Brian Repair Centre and Addenbrooke’s Hospital
- Cambridge, UK, 2004-2007
- Presentation on PET to American school students, Wolfson Brain Imaging Centre, Cambridge, UK, July 2007
- Poster presentation at the UK stroke forum 2007
- Several poster presentations in 17th European Stroke Conference, Nice, France, May 2008 (see publications)
Private Medical Practice
Founding Partner
NEUROMED – The Integrated Neurology Center (www.neuromedclinics.com)
- Established a private world-class medical center specializing in neurology & sleep medicine in Egypt
- Oversaw the growth and expansion of the center to a network of 5 branches across Cairo and to provide neurologic and sleep services to more than 50 hospitals in Cairo