Prof. Ali Shalash

Education
  • Graduated from Faculty of medicine -Ain Shams University – Cairo – Egypt 1998
  • MD Neurology from Ain Shams University – Cairo – Egypt 2007.
  • University profile: http://staff.asu.edu.eg//med-725
Current Position: Professor of Neurology, Faculty of Medicine, Ain Shams University
Unit(s)
Research
List of Publications
Skills & Interests
  • Member of International Parkinson & Movement Disorders Society (MDS).
  • Member of education committee of MDS.
  • Member of African Steering committee of MDS
  • Member of Telemedicine taskforce of MDS.
  • Director of Movement Disorders Clinic-Ain Shams Hospitals- Faculty of Medicine- Ain Shams University
  • Member of Egyptian Society of Neurology Neurosurgery & Psychiatry, Movement Disorders chapter, annual course coordinator.
  • Founder and clinical coordinator of Egyptian Network of Neurodegenerative diseases (ENND).
  • Former director of Neurology & Neurocritical care Units- Ain Shams Specialized Hospital (ASUS)- Cairo 2014
  • Former Director of Stroke Unit – ASUS, Cairo 2015.
Thesis

MD in Neurology April 2007 Faculty of Medicine, Ain Shams University, Cairo, Egypt MD thesis was on assessment and management of movement disorders, especially advances in surgical treatment. Title: Movement Disorders: Clinical and Electrophysiological Localization in Stereotactic Surgery. 2006 Grade: very good MSc in Neurology & Psychiatry Faculty of Medicine, Ain Shams University, Cairo, Egypt 2002 Taught courses in neuroanatomy, neurophysiology, biochemistry, neurohistology, neuropathology, psychopathology, psychology, clinical neurology, clinical psychiatry and internal medicine Thesis on; Neurology of pain

Training
  • Short Fellowship to Christian-Albrechts University Kiel, Germany: the Department to Department Program of the European Federation of Neurological Societies (EFNS) to departments of Neurology, Universitätsklinikum Schleswig-Holstein, Kiel Campus, Christian-Albrechts University Kiel, Germany under supervision of Prof Günther Deuschl (the past president of International Parkinson and Movement Disorders society and current president of European Academy of Neurology) in Oct & Nov 2012.
  • Short Fellowship to University colleague of London, London, UK: the Department to Department Program of the Parkinson’s disease and Movement Disorders Society (MDS) to departments of Neurology, University colleague of London, London, UK, in 2014.
  • Participating in MDS Summer School of International Parkinson & Movement Disorders Society (MDS) London 2013.
  • Participating in Summer School of European Academy of Neurology, Czech Republic 2014.
  • Participation in different International Parkinson & Movement Disorders Society Congresses; Dublin 202, Stockholm 2014, Berlin 2016, with poster presentations in all events.
  • EEG in the diagnosis & management of epilepsy – 5th edition of ILAE (International League Against Epilepsy); VIREPA 2010-2011.
  • EEG in the diagnosis & management of epilepsy in neonates and children – 1st edition; ILAE (International League Against Epilepsy); VIREPA, 2011- 2012.
  • Attendance of several courses and schools for movement disorders, botulinum toxin injection and other neurological disorders.
  • Speaker in several national and international conferences.
Publications

1) El Nahas NM, Shokri HM, Roushdy TM, Aref HM, Hamed SM, Shalash AS, Abdelrahem MI, Dawood NL, Abushady EM, Georgy SS, Zaki AS, Bedros RY. Urban Versus Rural Egypt: Stroke Risk Factors and Clinical Profile: Cross-Sectional Observational Study. J Stroke Cerebrovasc Dis. 2019 Aug 12:104316. doi: 10.1016/j.jstrokecerebrovasdis.2019.104316.

2) Nahas NE, Shokri H, Abdulghani O, Zakaria M, Kamel T, Fahmi N, Khayat N, Shalash A, Basiony AE, Reda R, Farag S, Tork M, Elbokl A, Abdelbaset I, Aref H. Clinical Characteristics of Borderzone Infarction in Egyptian Population. J Stroke Cerebrovasc Dis. 2019 Jan 16. pii: S1052-3057(19)30003-5. doi: 10.1016/j.jstrokecerebrovasdis.2019.01.003

3) Rösler TW, Salama M, Shalash AS, Khedr EM, El-Tantawy A, Fawi G, El-Motayam A, El-Seidy E, El-Sherif M, El-Gamal M, Moharram M, El-Kattan M, Abdel-Naby M, Ashour S, Müller U, Dempfle A, Kuhlenbäumer G, Höglinger GU. K-variant BCHE and pesticide exposure: Gene-environment interactions in a case-control study of Parkinson’s disease in Egypt. Sci Rep. 2018 Nov 8;8(1):16525. doi: 10.1038/s41598-018-35003-4.

4) Shalash AS, Hamid E, Elrassas HH, Bedair AS, Abushouk AI, Khamis M, Hashim M, Ahmed NS, Ashour S and Elbalkimy M (2018) Non-Motor Symptoms as Predictors of Quality of Life in Egyptian Patients with Parkinson’s Disease: A Cross-Sectional Study Using a Culturally Adapted 39-Item Parkinson’s Disease Questionnaire. Front. Neurol. 9:357. doi: 10.3389/fneur.2018.00357 4) 5) Mohamed Salama, Ali Shalash, Alshimaa Magdy, Marianne Makar, Tamer Roushdy, Mahmoud Elbalkimy, Hanan Elrassas, Passent Elkafrawy , Wael Mohamed, Mohamed B Abou Donia. Cytoskeletal proteins, Tubulin and Tau, as targets for diagnosis of Parkinson’s and Alzheimer’s diseases. PLOS One, 2018; 13(5): e0196436.

5) Ben-Pazi H, Browne P, Chan P, Cubo E, Guttman M, Hassan A, Hatcher-Martin J, Mari Z, Moukheiber E, Okubadejo NU, Shalash A; International Parkinson and Movement Disorder Society Telemedicine Task Force. The Promise of Telemedicine for Movement Disorders: an Interdisciplinary Approach. Curr Neurol Neurosci Rep. 2018 Apr 13;18(5):26. doi: 10.1007/s11910-018-0834-6.

6) Shalash Ali, Abushady Eman, Hamid Eman, Salama Mohamed, Ibrahim Yosra. Patient with hemiparkinsonism secondary to a gun pellet in the contralateral substantia nigra. Movement Disorders clinical practice, Nov 2017.

7) Shalash Ali, Mohamed Salama, Marianne Makar, Tamer Roushdy, Hanan Elrassas, Wael Mohamed, Mohamed B Abou Donia, Mahmoud El-Balkimy. Elevated Serum alpha-synuclein autoantibodies in patients with Parkinson’s disease relative to Alzheimer’s disease and controls. Front. Neurol. 2017 Dec 22; 8: 720.

8) Shalash Ali, MD, Thomas W. Rösler, PhD, Stefanie H. Müller, M.Sc., Mohamed Salama, MD, Günther Deuschl, MD, Ulrich Müller, MD, Thomas Opladen, , Britt Sabrina Petersen, PhD, Andre Franke, PhD, MD, Franziska Hopfner, MD, Gregor Kuhlenbäumer, MD, PhD, Günter U. Höglinger, MD. c.207C.G mutation in sepiapterin reductase causes autosomal dominant dopa-responsive dystonia. Neurol Genet. 2017 Nov 1;3(6): e197.; doi: 10.1212/ NXG.0000000000000197.

9) Christian Schlenstedt, Ali Shalash, Muthuraman Muthuraman, Daniela Falk, Karsten Witt, Günther Deuschl. Effect of high frequency subthalamic neurostimulation on gait and freezing of gait in Parkinson’s disease: a systematic review and meta-analysis. European journal of neurology 2017 Jan;24(1):18-26.

10) Mohamed Salama, Mahmoud Sobh, Mahmoud Emam, Ahmed Abdalla, Dina Sabry, Mohamed El-Gamal, Ahmed Lotfy, Mahmoud El-Husseiny, Mohamed Sobh, Ali Shalash Wael MY Mohamed. Intranasal Stem Cells Administration Rescues Nigrostriatal System in Parkinson’s Disease Mouse Model. Exp Ther Med. 2017 Mar;13(3):976-982.

11) Samia Ashour, Ahmed Gaber, Osama Aboelfotoh Aly, Saeed Hashem, Mohamed M Salama, Ali S Shalash. A Study of Extrapyramidal Manifestations Accompanying Decompensated Viral Hepatic Cirrhosis Patients. Reviews on Recent Clinical Trials. 2017 June;12:1-6.

12) Awad K, Abushouk AI, AbdelKarim AH, Mohammed M, Negida A, Shalash AS. Bee venom for the treatment of Parkinson’s disease: How far is it possible? Biomed Pharmacother. 2017 May 3;91:295-302.

13) Shalash AS, Hassan DM, Elrassas HH, Salama MM, Méndez-Hernández E, Salas-Pacheco JM, Arias-Carrión O. Auditory- and Vestibular-Evoked Potentials Correlate with Motor and Non-Motor Features of Parkinson’s Disease. Front Neurol. 2017 Feb 27;8:55.

14) Shalash, AS, Elrassas, HH, Monzem, MM, Salem, HS, Abdel Moneim, AN, and Moustafa RR. Restless Legs Syndrome in Egyptian medical students using a validated Arabic version of Restless Legs Syndrome Rating Scale. Sleep Medicine 16 (2015) 1528–1531.

15) Hussein HM, Abdel Moneim A, Emara T, Abd-Elhamid YA, Salem HH, Abd-Allah F, Farrag MA, Tork MA, Shalash AS, Ezz El Dein KH, Osman G, Georgy SS, Ghali PG, Lyden PD, Moustafa RR. Arabic cross cultural adaptation and validation of the National Institutes of Health Stroke Scale. J Neurol Sci. 2015 Jul 16. pii: S0022-510X(15)00443-8. doi: 10.1016/j.jns.2015.07.022.

16) Alexoudi A, Shalash AS, Knudsen K, Witt K, Mehdorn M, Volkmann J, Deuschl G. The medical treatment of patients with Parkinson’s disease receiving subthalamic neurostimulation. Parkinsonism Relat Disord. 2015; 2015 Jun;21(6):555-60.

17) Shalash AS, Elsayed SM, Elnaghi S, Schneider SA, Abdel Ghaffar TY. Prominent extensor truncal dystonia in Egyptian patients with Wilson’s disease. Movement disorders: official journal of the Movement Disorder Society 2014;29(1):151-153 (New observation).

18) Shalash A, Alexoudi A, Knudsen K, et al. The impact of age and disease duration on the long term outcome of neurostimulation of the subthalamic nucleus. Parkinsonism & related disorders 2014;20(1):47-52

19) Moustafa RR, Moneim AA, Salem HH, Shalash AS, Azmy HA. Intracranial steno-occlusive arterial disease and its associations in Egyptian ischemic stroke patients. Stroke. 2013 Feb;44(2):538-41.

20) Safeya Effat, Hanan Azzam, Ali Shalash, Seham Elkatan, Hanan Elrassas. Self-reported Quality of Life of Patients with Multiple Sclerosis with Mild Disability. Egypt J. Neurol. Psychiat. Neurosurg. 2016. Acceptance.

21) Tantawy AA, Andrawes NG, Adly AA, El Kady BA, Shalash AS. Retinal changes in children and adolescents with sickle cell disease attending a paediatric hospital in Cairo, Egypt: risk factors and relation to ophthalmic and cerebral blood flow. Transactions of the Royal Society of Tropical Medicine and Hygiene 2013;107(4):205-211

22) Shalash A, Sakr H, Gaber A. Structural Frontal Abnormalities in Idiopathic Dystonia Using Diffusion Tensor Imaging. Egypt J. Neurol. Psychiat. Neurosurg. July 2012 Vol. 49 3 : 213 – 217. Presented in XXth World Congress of Neurology (WCN), Marrakesh, 2011 (oral presentation).

23) Hussein MA, Moustafa B, and Shalash A. Targeting Vascular Cross Compression of Cranial nerves by MRI: diagnosis, characterization, and identification of prognostic factors affecting outcome of micro-vascular decompression. The Egyptian journal of Radiology & Nuc. Med., Vol.39 No.4(Dec.): 1613 -1622,2008.

24) Shalash AS, Abdel Ghany WA. Intraoperative Electrophysiological Monitoring During Selective Dorsal Rhizotomy in Children with Spastic Cerebral Palsy.. Egypt J. Neurol. Psychiat. Neurosurg. July 2010 Vol. 47 3 : 505 – 510.

25) El-khawas HM, Shalash AS, Said A, Zaki RG. Multimodal Visual Functions and Cerebrovascular Reactivity in Migraine Patients between Attacks. Egypt J. Neurol. Psychiat. Neurosurg. October 2010 Vol. 474 : 655 – 664.

26) Shalash AS, Abdelmaksoud AA, El-Shazly AA, Abdel-Mohsen E, Salem MA. Correlation between Peripheral Neuropathy and Ocular Surface Disorders in Children and Adolescents with Type 1 Diabetes Mellitus. Egypt J. Neurol. Psychiat. Neurosurg. October 2011 Vol. 48 4 : 337 – 343.

27) Reda WA, Gaber AA, Saoud K, Shalash AS. Combined Vim, Vop thalamotomy for Holmes’ Tremor: Four Years Follow Up. Egypt J. Neurol. Psychiat. Neurosurg. Acceptance 11 2011.

28) Shalash AS, El-Khawas HM, Tork MA. Clinical, Laboratory, and Imaging Characteristics of Strokes with Clinical Diffusion Mismatch. Egypt J. Neurol. Psychiat. Neurosurg. 2013; 50(4): 361-367.

29) Books • Shalash Ali. Guide to Neurology, parts 1&2 (textbook). 3rd edition 2015. Cairo. • Shalash Ali. Guide to Neurological Examination. 1st edition 2016.Cairo.

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