Prof. Ali Shalash

Professor of Neurology

Ain Shams University– Cairo, Egypt

  • Born in Cairo on December 4th, 1974.
  • Impact factor: Google scholar h index 32 i10 index 52
  • Recieved the following awards:
    • MDS-LEAP program award 2018.
    • Ain Shams University -Scientific research Award 2019-2022.
    • State Award (Individuals) 2019 (Prof. Osama Elwan) in neurological diseases, 2020.
Education
  • Graduated from Faculty of medicine -Ain Shams University – Cairo – Egypt 1998
  • MD Neurology from Ain Shams University – Cairo – Egypt 2007.
  • University profile: http://staff.asu.edu.eg//med-725
Current Position: Professor of Neurology, Faculty of Medicine, Ain Shams University
Unit(s)
Research
List of Publications
Skills & Interests

The positions assigned to:

  • Head of Movement Disorders Group-department of neurology, Faculty of Medicine, Ain Shams University.
  • Vice chair of MD chapter of Egyptian Society of Neurology.
  • Chair elect of International Parkinson & Movement Disorders Society-African section
  • Past Chair of education committee of International Parkinson & Movement Disorders Society-African section (MDS-AS) from 2022 till now.
  • Associate editor of MDCP Journal
  • Founder and head of Egyptian PD research group.
  • Member of Telemedicine, PD genetics, poststroke MD and pediatric taskforces of MDS.
  • Consultant with the WHO for launching of PD: a public health approach: technical brief and PD global disparities.
  • Member of education committee of MDS 2017-2019.
  • Founder and clinical coordinator of Egyptian Network of Neurodegenerative diseases (ENND).
  • Former director of Neurology & Neurocritical care Unit, stroke , Ain Shams Specialized Hospital, Cairo 2014-15.
Thesis

MD in Neurology April 2007 Faculty of Medicine, Ain Shams University, Cairo, Egypt MD thesis was on assessment and management of movement disorders, especially advances in surgical treatment. Title: Movement Disorders: Clinical and Electrophysiological Localization in Stereotactic Surgery. 2006 Grade: very good MSc in Neurology & Psychiatry Faculty of Medicine, Ain Shams University, Cairo, Egypt 2002 Taught courses in neuroanatomy, neurophysiology, biochemistry, neurohistology, neuropathology, psychopathology, psychology, clinical neurology, clinical psychiatry and internal medicine Thesis on; Neurology of pain

Training
  • WHO meeting in Geneva 5-6 September 2023; invited as an expert in WHO meeting “Improving access to medicines for neurological disorders”.
  • Short Fellowship to Christian-Albrechts University Kiel, Germany: (EAN)in Oct & Nov 2012.
  • Participation in different International Parkinson & Movement Disorders Society Congresses; Dublin 202, Stockholm 2014, Berlin 2016, 2017- to 2024with poster presentations in all events.
  • Participation in MDS congress 2019, 2022 as faculty.
  • MDS LEAP program graduation, class 2018.
  • Director and founder of several MDS courses; 1st MDS Africa school 2019, African Movement Disorders Grand Round 2020, MDS Africa online course; principles of MDs 2020, skill workshop 2023
  • Attendance of several courses and schools for movement disorders, botulinum toxin injection and other neurological disorders.
  • Speaker in several national and international conferences.
  • Reviewer in national and international neurological journals; frontier Neurology, R. Translational Neurodegeneration, PLOS1, Egyptian journal of neurology, psychiatry & neurosurgery.
Publications

Prof Shalash led and participated in international and national research in PD, tremor, genetics, telemedicine, and other fields

  • Editor of book: Movement Disorders in Neurology and Systemic Disorders: Movement Disorders in Neurology and Systemic Disorders. 1st Edition, Volume 8 – November 12, 2024. Editors: Pramod Kumar Pal, Ali Shalash
  • Khedr EM, William MB, Elhosseiny AA, Shalash A, Fawi G, Yousef MH, El-Jaafary S, Lee H, Jama A, Koraym M, Helmy A, Salah Y, George P, Haridy NA, Nabhan S, Atputhavadivel A, Elfarrash S, Ragab G, Hegazy MT, Elsaid Y, Gabr AS, Shebl N, Aly L, Abdelwahhab N, Belal TM, Elsayed NAB, El-Gamal M, Elgamal S, Ragab S, Mekky J, Houlden H, Rizig M, Salama M. APOE genetic variability in an Egyptian cohort of PD. Front Neurosci. 2025 May 23;19:1579968. doi: 10.3389/fnins.2025.1579968. PMID: 40486732; PMCID: PMC12141286.
  • Ortega-Robles E, Shalash A, Ramírez-Bermúdez J, Arias-Carrión O. Functional Movement Disorder: Evolving Mechanisms, Diagnostic Precision, and Personalized Multidisciplinary Care. Mov Disord Clin Pract. 2025 May 19. doi: 10.1002/mdc3.70136. Epub ahead of print. PMID: 40387286.
  • Shalash AS, Badr MY, Salah Y, Elgamal S, Elaidy SA, Elhamrawy EA, Abdel-Tawab H, Hamid E, El-Seidy EA, Dawood NL; Egyptian Parkinson Research Group. Gastrointestinal Manifestations in Parkinson’s Disease Using a Validated Arabic Version of Gastrointestinal Dysfunction Scale: A Multicenter Study. Mov Disord Clin Pract. 2025 Mar 15. doi: 10.1002/mdc3.70005. Epub ahead of print. PMID: 40088075.
  • Gracies JM, …, Shalash AS, ….Wissel J; Spasticity Study Group of the International Parkinson and Movement Disorders Society. Spastic Paresis: A Treatable Movement Disorder. Mov Disord. 2025 Jan;40(1):44-50. doi: 10.1002/mds.30038. Epub 2024 Nov 16. PMID: 39548808; PMCID: PMC11752976.
  • Arias-Carrion O, Ortega-Robles E, Ortuno-Sahagun D, Ramirez-Bermudez J, Hamid A, Shalash A. Sleep-Related Disorders in Parkinson’s Disease: Mechanisms, Diagnosis, and Therapeutic Approaches. CNS Neurol Disord Drug Targets. 2025;24(2):132-143. doi: 10.2174/0118715273314675240820191447. PMID: 39238379.
  • William MB, .. Shalash A, …….Rizig M. The p.Gly2019Ser is a common LRRK2 pathogenic variant among Egyptians with familial and sporadic Parkinson’s disease. NPJ Parkinsons Dis. 2024 Nov 6;10(1):215. doi: 10.1038/s41531-024-00826-8. PMID: 39505921; PMCID: PMC11541850.
  • Shalash A, …..; Egyptian Parkinson Research Group. Pain Characteristics of Parkinson’s Disease Using Validated Arabic Versions of the King’s Parkinson’s Disease Pain Scale and Questionnaire: A Multicenter Egyptian Study. J Mov Disord. 2024 Oct;17(4):387-397. doi: 10.14802/jmd.24088. Epub 2024 Jun 25. PMID: 38915261; PMCID: PMC11540543.
  • Essam M, ……, Shalash A. Role of zonisamide in advanced Parkinson’s disease: a randomized placebo-controlled study. Neurol Sci. 2024 Apr;45(4):1725-1734. doi: 10.1007/s10072-024-07396-w. Epub 2024 Feb 20. PMID: 38376645; PMCID: PMC10943138.
  • George P, ….., Shalash A. The clinical and neuroimaging differences between vascular parkinsonism and Parkinson’s disease: a case-control study. BMC Neurol. 2024 Feb 6;24(1):56. doi: 10.1186/s12883-024-03556-9. PMID: 38321372; PMCID: PMC10845551.
  • Meshref M, ….., Shalash A, Bahbah EI. The Role of RIN3 Gene in Alzheimer’s Disease Pathogenesis: a Comprehensive Review. Mol Neurobiol. 2023 Nov 23. doi: 10.1007/s12035-023-03802-0. Epub ahead of print. PMID: 37995081.
  • Shalash A, et al. Tremor in Patients with Relapsing-Remitting Multiple Sclerosis: Clinical Characteristics and Impact on Quality of Life. Mov Disord Clin Pract. 2023 May 26;10(7):1099-1106. doi: 10.1002/mdc3.13784. PMID: 37476314; PMCID: PMC10354614.
  • Saunders-Pullman R….., Shalash …..Simuni T. International Genetic Testing and Counseling Practices for Parkinson’s Disease. Mov Disord. 2023 Aug;38(8):1527-1535. doi: 10.1002/mds.29442. Epub 2023 Jun 13. PMID: 37310233; PMCID: PMC10461455.
  • Pringsheim T, …. Shalash A, …. Roze E. Transitional Care for Young People with Movement Disorders: Consensus-Based Recommendations from the MDS Task Force on Pediatrics. Mov Disord Clin Pract. 2023 Apr 4;10(5):748-755. doi: 10.1002/mdc3.13728. PMID: 37205244; PMCID: PMC10186998.
  • Hamid E, …., Shalash A. The Gaps and Prospects of Movement Disorders Education and Research in Africa: A Continental Survey. Mov Disord. 2023 Feb;38(2):178-184. doi: 10.1002/mds.29313. Epub 2023 Jan 26. PMID: 36703239.
  • Local Burden of Disease Household Air Pollution Collaborators. Mapping development and health effects of cooking with solid fuels in low-income and middle-income countries, 2000-18: a geospatial modelling study. Lancet Glob Health. 2022 Oct;10(10):e1395-e1411. doi: 10.1016/S2214-109X(22)00332-1. PMID: 36113526; PMCID: PMC9638039.
  • Shalash A, et al. Guillain-Barré syndrome following different COVID-19 vaccines: a case series. Egypt J Neurol Psychiatr Neurosurg. 2022;58(1):153. doi: 10.1186/s41983-022-00582-7. Epub 2022 Dec 9. PMID: 36532828; PMCID: PMC9734843.
  • Shalash A, et al. A 6-month longitudinal study on worsening of Parkinson’s disease during the COVID-19 pandemic. NPJ Parkinsons Dis. 2022 Aug 31;8(1):111..
  • Schiess N, …. Shalash A, ……. Six Action Steps to Address Global Disparities in Parkinson Disease: A World Health Organization Priority. JAMA Neurol. 2022 Jul 11. doi: 10.1001/jamaneurol.2022.1783. Epub ahead of print. PMID: 35816299.
  • Ratliff JB, Schaefer SM, Chitnis S, Cooney JW, Hess CW, Okubadejo N, Shalash A, Moro E, Sue C, Pandey S, Pal PK, Yang L. Viewpoint on Milestones for Fellowship Training in Movement Disorders. Mov Disord. 2022 Jul 11.
  • Meshref M, Ghaith HS, Hammad MA, Shalaby MMM, Ayasra F, Monib FA, Attia MS, Ebada MA, Elsayed H, Shalash A, Bahbah EI. The Role of RIN3 Gene in Alzheimer’s Disease Pathogenesis: a Comprehensive Review. Mol Neurobiol. 2023 Nov 23. doi: 10.1007/s12035-023-03802-0. Epub ahead of print. PMID: 37995081.
  • McGovern E, Pringsheim T, Medina A, Cosentino C, Shalash A, Sardar Z, Fung VSC, Kurian MA, Roze E; MDS Task Force on Pediatrics. Transitional Care for Young People with Neurological Disorders: A Scoping Review with A Focus on Patients with Movement Disorders. Mov Disord. 2021 Jun;36(6):1316-1324. doi: 10.1002/mds.28381. Epub 2020 Nov 17. PMID: 33200525.
  • Hamid E, Okengo K, Ayele BA, Gams Massi D, Ben Sassi S, Tibar H, El-Sadig SM, Mahoui S, Razafimahefa J, Kouame-Assouan AE, Ben-Adji D, Modeste LYT, Mohamed MH, Nsengiyumva N, Alwahchi WA, Neshuku SN, Ocampo C, Sakadi F, Caiano JB, Rodrigues Fortes A, Fall M, Ngwende GW, Hooker J, Charway-Felli A, Atadzhanov M, Carr J, Okubadejo NU, Shalash A. The Gaps and Prospects of Movement Disorders Education and Research in Africa: A Continental Survey. Mov Disord. 2023 Feb;38(2):178-184. doi: 10.1002/mds.29313. Epub 2023 Jan 26. PMID: 36703239.
  • Local Burden of Disease Household Air Pollution Collaborators. Mapping development and health effects of cooking with solid fuels in low-income and middle-income countries, 2000-18: a geospatial modelling study. Lancet Glob Health. 2022 Oct;10(10):e1395-e1411. doi: 10.1016/S2214-109X(22)00332-1. PMID: 36113526; PMCID: PMC9638039.
  • Shalash A, Belal N, Zaki AS, Georgy SS, Doheim MF, Hazzou A, Abdelnasser A. Guillain-Barré syndrome following different COVID-19 vaccines: a case series. Egypt J Neurol Psychiatr Neurosurg. 2022;58(1):153.
  • Shalash A, Helmy A, Salama M, Gaber A, El-Belkimy M, Hamid E. A 6-month longitudinal study on worsening of Parkinson’s disease during the COVID-19 pandemic. NPJ Parkinsons Dis. 2022 Aug 31;8(1):111. doi: 10.1038/s41531-022-00376-x. PMID: 36045133; PMCID: PMC9428872.
  • Shalash A, Helmy A, Salama M, Gaber A, El-Belkimy M, Hamid E. A 6-month longitudinal study on worsening of Parkinson’s disease during the COVID-19 pandemic. NPJ Parkinsons Dis. 2022 Aug 31;8(1):111. doi: 10.1038/s41531-022-00376-x. PMID: 36045133; PMCID: PMC9428872.
  • Abbas A, Moustafa R, Shalash A, Haroun M, Amin R, Borham S, Elsadek A, Helmy S. Serum CGRP Changes following Ultrasound-Guided Bilateral Greater-Occipital-Nerve Block. Neurol Int. 2022 Feb 7;14(1):199-206. doi: 10.3390/neurolint14010016. PMID: 35225886; PMCID: PMC8883968.
  • Helmy A, Hamid E, Salama M, Gaber A, El-Belkimy M, Shalash A. Baseline predictors of progression of Parkinson’s disease in a sample of Egyptian patients: clinical and biochemical. Egypt J Neurol Psychiatr Neurosurg. 2022;58(1):9. doi: 10.1186/s41983-022-00445-1. Epub 2022 Jan 15. PMID: 35068922; PMCID: PMC8760567.
  • Ayele BA, Demissie H, Awraris M, Amogne W, Shalash A, Ali K, Zenebe Y, Tafesse A, Venkatasubba Rao CP. SARS-COV-2 induced Parkinsonism: The first case from the sub-Saharan Africa. Clin Park Relat Disord. 2021;5:100116. doi: 10.1016/j.prdoa.2021.100116. Epub 2021 Nov 11. PMID: 34786554; PMCID: PMC8582125.
  • Cook L, Schulze J, Verbrugge J, Beck JC, Marder KS, Saunders-Pullman R, Klein C, Naito A, Alcalay RN; ClinGen Parkinson’s Disease Gene Curation Expert Panel and the MDS Task Force for Recommendations for Genetic Testing in Parkinson’s Disease; Clinical Genome Resource (ClinGen) Parkinson’s Disease Gene Curation Expert Panel Authors; Movement Society Disorder (MDS) Task Force on Recommendations for Clinical Genetic Testing in Parkinson’s Disease Authors. The commercial genetic testing landscape for Parkinson’s disease. Parkinsonism Relat Disord. 2021 Nov;92:107-111. doi: 10.1016/j.parkreldis.2021.10.001. Epub 2021 Oct 19. PMID: 34696975; PMCID: PMC8633166.
  • Kinyoki D, Osgood-Zimmerman AE, Bhattacharjee NV; Local Burden of Disease Anaemia Collaborators, Kassebaum NJ, Hay SI. Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018. Nat Med. 2021 Oct;27(10):1761-1782. doi: 10.1038/s41591-021-01498-0. Epub 2021 Oct 12. PMID: 34642490; PMCID: PMC8516651.
  • Elrassas HH, Elsayed YAR, Abdeen MS, Shady MM, Shalash A, Morsy M. Restless Legs Syndrome among patients receiving antipsychotic and antidepressant drugs. Hum Psychopharmacol. 2021 Sep 17:e2817. doi: 10.1002/hup.2817. Epub ahead of print. PMID: 34533852.
  • GBD 2019 Under-5 Mortality Collaborators. Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burden of Disease Study 2019. Lancet. 2021 Sep 4;398(10303):870-905. doi: 10.1016/S0140-6736(21)01207-1. Epub 2021 Aug 17. PMID: 34416195; PMCID: PMC8429803.
  • Farag S, Kenawy FF, Shokri HM, Zakaria M, Aref H, Fahmi N, Khayat N, Shalash A, Nahas NE. The Clinical Characteristics of Patients with Pre-Existing Leukoaraiosis Compared to Those Without Leukoaraiosis in Acute Ischemic Stroke. J Stroke Cerebrovasc Dis. 2021 Jun 30;30(9):105956. doi: 10.1016/j.jstrokecerebrovasdis. 2021.105956. Epub ahead of print. PMID: 34217070.
  • Shalash AS, Rösler TW, Abdelrahman IY, Abulmakarem HS, Müller SH, Hopfner F, Kuhlenbäumer G, Höglinger GU, Salama M. Atypical pantothenate kinase-associated neurodegeneration with variable phenotypes in an Egyptian family. Heliyon. 2021 Jul 2;7(7):e07469. doi: 10.1016/j.heliyon.2021.e07469. PMID: 34286134; PMCID: PMC8273219.
  • Hamid E, Ayele BA, Massi DG, Ben Sassi S, Tibar H, Djonga EE, El-Sadig SM, Amer El Khedoud W, Razafimahefa J, Kouame-Assouan AE, Ben-Adji D, Lengané YTM, Musubire AK, Mohamed MH, Phiri TE, Nestor N, Alwahchi WA, Neshuku SN, Ocampo C, Sakadi F, Maidal MA, Ngwende GW, Hooker J, Okeng’o K, Charway-Felli A, Atadzhanov M, Carr J, Okubadejo NU, Shalash A. Availability of Therapies and Services for Parkinson’s Disease in Africa: A Continent-Wide Survey. Mov Disord. 2021 Jun 3. doi: 10.1002/mds.28669. Epub ahead of print. PMID: 34080713.
  • Shalash AS, Rösler TW, Salama M, Pendziwiat M, Müller SH, Hopfner F, Höglinger GU, Kuhlenbäumer G. Evidence for pathogenicity of variant ATM Val1729Leu in a family with ataxia telangiectasia. Neurogenetics. 2021 Mar 29. doi: 10.1007/s10048-021-00639-4. Epub ahead of print. PMID: 33779842.
  • Shalash A, Spindler M, Cubo E. Global Perspective on Telemedicine for Parkinson’s Disease. J Parkinsons Dis. 2021 Feb 8. doi: 10.3233/JPD-202411. Epub ahead of print. PMID: 33579872.
  • Shalash AS, Hamid E, Elrassas H, Bahbah EI, Mansour AH, Mohamed H, Elbalkimy M. Non-motor symptoms in essential tremor, akinetic rigid and tremor-dominant subtypes of Parkinson’s disease. PLoS One. 2021 Jan 27;16(1):e0245918. doi: 10.1371/journal.pone.0245918. PMID: 33503062; PMCID: PMC7840014.
  • Local Burden of Disease Vaccine Coverage Collaborators. Mapping routine measles vaccination in low- and middle-income countries. Nature. 2021 Jan;589(7842):415-419. doi: 10.1038/s41586-020-03043-4. Epub 2020 Dec 16. PMID: 33328634; PMCID: PMC7739806.
  • McGovern E, Pringsheim T, Medina A, Cosentino C, Shalash A, Sardar Z, Fung VSC, Kurian MA, Roze E; MDS Task Force on Pediatrics. Transitional Care for Young People with Neurological Disorders: A Scoping Review with A Focus on Patients with Movement Disorders. Mov Disord. 2020 Nov 17. doi: 10.1002/mds.28381. Epub ahead of print. PMID: 33200525.
  • Shalash A, Fathy M, Dawood NL, Hamid E. Adopting Virtual Visits for Parkinson’s Disease Patients During the COVID-19 Pandemic in a Developing Country. Front Neurol. 2020 Oct 27;11:582613. doi: 10.3389/fneur.2020.582613. PMID: 33193042; PMCID: PMC7652791.
  • Ayele BA, Zenebe Y, Demissie H, Tafesse A, Melka D, Debebe Y, Tsehayneh F, Awraris M, Shalash A. Impact of COVID-19 on the clinical care of Ethiopian PD patients: A glimpse into the burden. eNeurologicalSci. 2020 Dec; 21:100273. doi: 10.1016/j.ensci.2020.100273. Epub 2020 Sep 15.
  • Shalash A, Fayed ZY, Hamid E, Radwan H, Nada MA, Eid M, Abdel Ghany WA. Outcome of pallidal stimulation of idiopathic generalized dystonia with predominant mobile truncal dystonia: case report. Int J Neurosci. 2020 Sep 16:1-5. doi:
  • Hassan A, Mari Z, Gatto EM, Cardozo A, Youn J, Okubadejo N, Bajwa JA, Shalash A, Fujioka S, Aldaajani Z, Cubo E; International Telemedicine Study Group. Global Survey on Telemedicine Utilization for Movement Disorders During the COVID-19 Pandemic. Mov Disord. 2020 Oct;35(10):1701-1711.
  • Shalash A, Okubadejo NU, Doumbe J, et al. Translation, Validation, Diagnostic Accuracy, and Reliability of Screening Questionnaire for Parkinsonism in Three African Countries. J Parkinsons Dis. 2020;10.3233/JPD-202040. doi:10.3233/JPD-202040.
  • Shalash A, Roushdy T, Essam M, et al. Mental health, physical activity and quality of life in Parkinson’s disease during COVID-19 pandemic [published online ahead of print, 2020 May 19]. Mov Disord. 2020;10.1002/mds.28134. doi:10.1002/mds.28134
  • Shalash A, Hamid E, Elrassas H, Abushouk AI, Salem HH. Sexual dysfunction in male patients with Parkinson’s disease: related factors and impact on quality of life. Neurol Sci. 2020.
  • Shalash AS, Mohamed H, Mansour AH, et al. Clinical Profile of Non-Motor Symptoms in Patients with Essential Tremor: Impact on Quality of Life and Age-Related Differences. Tremor Other Hyperkinet Mov (N Y). 2019;9:10.7916/tohm.v0.736.
  • Shalash AS, Hamid E, Elrassas HH, Bedair AS, Abushouk AI, Khamis M, Hashim M, Ahmed NS, Ashour S and Elbalkimy M (2018) Non-Motor Symptoms as Predictors of Quality of Life in Egyptian Patients with Parkinson’s Disease: A Cross-Sectional Study Using a Culturally Adapted 39-Item Parkinson’s Disease Questionnaire. Front. Neurol. 9:357. doi: 10.3389/fneur.2018.00357
  • Mohamed Salama, Ali Shalash, Alshimaa Magdy, Marianne Makar, Tamer Roushdy, Mahmoud Elbalkimy, Hanan Elrassas, Passent Elkafrawy , Wael Mohamed, Mohamed B Abou Donia. Cytoskeletal proteins, Tubulin and Tau, as targets for diagnosis of Parkinson’s and Alzheimer’s diseases. PLOS One, 2018; 13(5): e0196436.
  • Shalash Ali, Mohamed Salama, Marianne Makar, Tamer Roushdy, Hanan Elrassas, Wael Mohamed, Mohamed B Abou Donia, Mahmoud El-Balkimy. Elevated Serum alpha-synuclein autoantibodies in patients with Parkinson’s disease relative to Alzheimer’s disease and controls. Front. Neurol. 2017 Dec 22; 8: 720.
  • Shalash AS, Hassan DM, Elrassas HH, Salama MM, Méndez-Hernández E, Salas-Pacheco JM, Arias-Carrión O. Auditory- and Vestibular-Evoked Potentials Correlate with Motor and Non-Motor Features of Parkinson’s Disease. Front Neurol. 2017 Feb 27;8:55.
  • Shalash, AS, Elrassas, HH, Monzem, MM, Salem, HS, Abdel Moneim, AN, and Moustafa RR. Restless Legs Syndrome in Egyptian medical students using a validated Arabic version of Restless Legs Syndrome Rating Scale. Sleep Medicine 16 (2015) 1528–1531.
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